Our main interest is to the study the structural and functional properties of intrinsically disordered proteins and their involvement in various diseases. We develop various computational tools to aid research in this field, including prediction tools (e.g. IUPred and IUPred2A, ANCHOR) and databases (e.g. DIBS, PhaSePro). As many disordered proteins function through short linear motifs, we are also interested in how such functional sites can be identified from the amino acid sequence. We also study specific linear motif systems using a combination of computational and experimental methods. In particular, we are exploring the interaction partners of the dynein light chain LC8, and specific E3 ligases, such as SIAH.