{"id":24,"date":"2016-12-20T08:39:21","date_gmt":"2016-12-20T08:39:21","guid":{"rendered":"http:\/\/dlab.elte.hu\/?page_id=24"},"modified":"2025-09-02T13:55:34","modified_gmt":"2025-09-02T13:55:34","slug":"home","status":"publish","type":"page","link":"https:\/\/dlab.elte.hu\/","title":{"rendered":"Home"},"content":{"rendered":"<p style=\"text-align: justify;\">Our main interest is to the study the structural and functional properties of intrinsically disordered proteins and their involvement in various diseases. We develop various computational tools to aid research in this field, including prediction tools (e.g. IUPred and IUPred2A, ANCHOR) and databases (e.g. DIBS, PhaSePro). As many disordered proteins function through short linear motifs, we are also interested in how such functional sites can be identified from the amino acid sequence. We also study specific linear motif systems using a combination of computational and experimental methods. In particular, we are exploring the interaction partners of the dynein light chain LC8, and specific E3 ligases, such as SIAH.<\/p>\n<p><a href=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/20250612_201032-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-762 size-large\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/20250612_201032-1024x768.jpg\" alt=\"\" width=\"640\" height=\"480\" srcset=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/20250612_201032-1024x768.jpg 1024w, https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/20250612_201032-300x225.jpg 300w, https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/20250612_201032-768x576.jpg 768w, https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/20250612_201032-1536x1152.jpg 1536w, https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/20250612_201032-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\">We are coordinating the <a href=\"https:\/\/idp2biomed.eu\" target=\"_blank\" rel=\"noopener\">IDP2Biomed<\/a> twinning rant. Our group is also involved in EU funded projects <a href=\"https:\/\/idpro.elte.hu\" target=\"_blank\" rel=\"noopener\">IDPro<\/a> and IDPFun2. We are coordinating the Twinning grant starting in October 1st, 2024 with partners Prof. Michele Vendruscolo (University of Cambridge), Prof. Markus Zweckstetter (German Center for Neurodegenerative Diseases), Prof. Silvio Tossato (University of Padova).<\/p>\n<hr \/>\n<h2>Selected publications<\/h2>\n<ul>\n<li><strong>AIUPred: combining energy estimation with deep learning for the enhanced prediction of protein disorder<br \/>\n<\/strong>G\u00e1bor Erd\u0151s, Zsuzsanna Doszt\u00e1nyi<strong><br \/>\n<\/strong> Nucleic Acids Research, Volume 52, Issue W1, 5 July 2024, Pages W176\u2013W181, <a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae385\">https:\/\/doi.org\/10.1093\/nar\/gkae385<\/a><\/li>\n<li aria-level=\"1\"><strong>Tutorial: a guide for the selection of fast and accurate computational tools for the prediction of intrinsic disorder in proteins<\/strong><br \/>\nL. Kurgan, G. Hu, K. Wang, S. Ghadermarzi, B. Zhao, N. Malhis, G. Erd\u0151s, J. Gsponer, V. N. Uversky, Zs. Doszt\u00e1nyi<br \/>\nNature Protocols, 2023, 10.1038\/s41596-023-00876-x<\/li>\n<li aria-level=\"1\"><strong>DisCanVis: Visualizing integrated structural and functional annotations to better understand the effect of cancer mutations located within disordered proteins<\/strong><br \/>\nNorbert Deutsch, M\u00e1ty\u00e1s Pajkos, G\u00e1bor Erd\u0151s, Zsuzsanna Doszt\u00e1nyi<br \/>\nProtein Science, 2023 Jan;32(1):e4522. doi: 10.1002\/pro.4522.<\/li>\n<li><strong>The interaction between LC8 and LCA5 reveals a novel oligomerization function of LC8 in the ciliary-centrosome system<\/strong><br \/>\nTam\u00e1s Szaniszl\u00f3, M\u00e1t\u00e9 F\u00fcl\u00f6p, M\u00e1ty\u00e1s Pajkos, G\u00e1bor Erd\u0151s, R\u00e9ka \u00c1gnes Kov\u00e1cs, Henrietta Vad\u00e1szi, J\u00f3zsef Kardos &amp; Zsuzsanna Doszt\u00e1nyi<br \/>\nScientific Reports volume 12, Article number: 15623 (2022)<\/li>\n<li><strong>Deep Learning for Intrinsically Disordered Proteins: From Improved Predictions to Deciphering Conformational Ensembles<\/strong><br \/>\nG\u00e1bor Erd\u0151s, Zsuzsanna Doszt\u00e1nyi<br \/>\nCurrent Opinion in Structural Biology, Volume 89, December 2024, 102950<\/li>\n<\/ul>\n<hr \/>\n<h2>Services<\/h2>\n\n<table id=\"tablepress-1\" class=\"tablepress tablepress-id-1 tbody-has-connected-cells\">\n<tbody>\n<tr class=\"row-1\">\n\t<td class=\"column-1\"><a href='https:\/\/aiupred.elte.hu\/'><br \/>\n<img src='https:\/\/aiupred.elte.hu\/static\/assets\/aiupred_v1_transparent.png' width=\"150\" height=\"90\" class=\"alignleft size-medium wp-image-493\"><br \/>\n<\/a><\/td><td class=\"column-2\">AIUPred: Prediction of Intrinsically Unstructured Proteins<\/td>\n<\/tr>\n<tr class=\"row-2\">\n\t<td class=\"column-1\"><a href=\"https:\/\/discanvis.elte.hu\/\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2025\/09\/discanvis.jpeg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-730\" \/><\/a><\/td><td class=\"column-2\">DisCanVis: Integrating structural and functional annotations for the better understanding of the effect of cancer mutations located within disordered proteins.<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\"><a href=\"https:\/\/iupred3.elte.hu\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/iupred3.elte.hu\/static\/iupred3.png\" alt=\"\" width=\"150\" height=\"90\" class=\"alignleft size-medium wp-image-493\" \/><\/a><\/td><td class=\"column-2\">IUPred3: Prediction of protein disorder enhanced with unambiguous experimental annotation and visualization of evolutionary conservation<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/memmorf.hegelab.org\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/memmorf.hegelab.org\/static\/assets\/mmlogo100.png\" alt=\"\" width=\"150\" height=\"70\" class=\"alignleft size-medium wp-image-493\" \/><\/a><\/td><td class=\"column-2\">MemMoRF is a comprehensive database of transmembrane and membrane associated proteins with MemMoRFs: regions that undergo disorder-to-order transition or large conformational changes upon membrane association.<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\"><a href=\"https:\/\/iupred2a.elte.hu\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/iupred2a-300x180.png\" alt=\"\" width=\"150\" height=\"90\" class=\"alignleft size-medium wp-image-493\" srcset=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/iupred2a-300x180.png 300w, https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/iupred2a-768x461.png 768w, https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/iupred2a.png 1000w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td><td class=\"column-2\">IUPred2A: Prediction of Intrinsically Unstructured Proteins<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\"><a href=\"https:\/\/phasepro.elte.hu\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/phaseseparation_art-300x194.png\" alt=\"\" width=\"150\" height=\"75\" class=\"alignleft size-medium wp-image-517\" \/><\/a><\/td><td class=\"column-2\">PhaSePro: A comprehensive database of proteins driving liquid-liquid phase separation (LLPS) in living cells.<\/td>\n<\/tr>\n<tr class=\"row-7\">\n\t<td colspan=\"2\" class=\"column-1\"><b>Additional web servers and databases we are involved in<\/b><br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-8\">\n\t<td class=\"column-1\"><a href=\"http:\/\/dibs.enzim.ttk.mta.hu\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/DIBS-jobb-1-300x138.png\" alt=\"\" width=\"150\" height=\"75\" class=\"alignleft size-medium wp-image-526\" \/><\/a><\/td><td class=\"column-2\">Disordered Binding Site (DIBS) database is a repository for protein complexes that are formed between Intrinsically Disordered Proteins (IDPs) and globular\/ordered partner proteins.<\/td>\n<\/tr>\n<tr class=\"row-9\">\n\t<td class=\"column-1\"><a href=\"http:\/\/mobidb.bio.unipd.it\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/mobidb-300x65.png\" alt=\"\" width=\"150\" height=\"30\" class=\"alignleft size-medium wp-image-532\" \/><\/a><\/td><td class=\"column-2\">MobiDB: A database of protein disorder and mobility annotations<\/td>\n<\/tr>\n<tr class=\"row-10\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.disprot.org\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/DisProt_prot_vect_brownonly-300x88.png\" alt=\"\" width=\"150\" height=\"45\" class=\"alignleft size-medium wp-image-534\" srcset=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/DisProt_prot_vect_brownonly-300x88.png 300w, https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/DisProt_prot_vect_brownonly.png 392w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/td><td class=\"column-2\">DisProt: A database of intrisically disordered proteins.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-1 from cache -->\n<h2>Funding<\/h2>\n\n<table id=\"tablepress-2\" class=\"tablepress tablepress-id-2\">\n<tbody>\n<tr class=\"row-1\">\n\t<td class=\"column-1\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/lendulet_logo_680_454_1513335128-300x201.jpg\" alt=\"\" width=\"100\" height=\"201\" class=\"alignleft size-medium wp-image-487\" \/><\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/logokek_nagy2-300x117.jpg\" alt=\"\" width=\"100\" height=\"117\" class=\"alignleft size-medium wp-image-539\" \/><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/elixir_logo-300x226.png\" alt=\"\" width=\"100\" height=\"226\" class=\"alignleft size-medium wp-image-488\" \/><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/IDPfun_padded_darkblue-300x187.png\" alt=\"\" width=\"100\" height=\"187\" class=\"alignleft size-medium wp-image-489\" \/><\/td><td class=\"column-5\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dlab.elte.hu\/wp-content\/uploads\/2019\/09\/download-300x168.png\" alt=\"\" width=\"100\" height=\"168\" class=\"alignleft size-medium wp-image-490\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-2 from cache -->\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our main interest is to the study the structural and functional properties of intrinsically disordered proteins and their involvement in various diseases. We develop various computational tools to aid research in this field, including prediction tools (e.g. IUPred and IUPred2A, &hellip; <a href=\"https:\/\/dlab.elte.hu\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"onecolumn-page.php","meta":{"footnotes":""},"class_list":["post-24","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/pages\/24","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/comments?post=24"}],"version-history":[{"count":37,"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/pages\/24\/revisions"}],"predecessor-version":[{"id":780,"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/pages\/24\/revisions\/780"}],"wp:attachment":[{"href":"https:\/\/dlab.elte.hu\/index.php\/wp-json\/wp\/v2\/media?parent=24"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}